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"Predictors and Health Outcomes of Treatment-Resistant Depression amon" by Drishti Shah
Predictors and Health Outcomes of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder. Drishti ShahWest Virginia University Follow. Understanding major depressive disorder MDD as a comorbidity in patients with chronic non-cancer pain conditions CNPC is of importance because of the high prevalence and well documented bi-directional relationship between MDD and pain. Furthermore, presence of CNPC among adults with MDD often reduces benefits of antidepressant therapy, thereby increasing the possibility of treatment resistance.
Treatment-resistant depression TRD commonly defined as insufficient response to multiple antidepressant trials, often worsens depression and pain symptoms and can amplify the clinical and economic burden among adults with CNPC and MDD.
Additionally, long-term opioid therapy LTOT may be prescribed at a higher rate to adults with TRD to treat an phd dissertation cnpc state of physical and mental pain, despite lack phd dissertation cnpc evidence on LTOT use in this patient population.
Existing literature on TRD phd dissertation cnpc focused on all adults with MDD. Owing to the lack of research on TRD among adults with CNPC and MDD, we conducted this study to fill a critical knowledge gap. This dissertation pursued three related aims: 1 identify leading predictors of TRD; 2 estimate the direct economic burden associated with TRD and identify factors that contribute to the excess cost burden of TRD; and 3 examine the trajectory of LTOT use in adults with CNPC and newly diagnosed MDD and how TRD can alter this trajectory.
TRD was identified using a comprehensive claims-based algorithm. First, we identified the use of mental health specialist visits, polypharmacy, psychotherapy use, anxiety, and age to be the five leading predictors of TRD using random forest, a machine learning method and cross-validated logistic regression. Shah, Drishti, "Predictors and Health Outcomes of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder" Graduate Theses, Dissertations, and Problem Reports.
Clinical Psychology CommonsEpidemiology CommonsMental Disorders CommonsMusculoskeletal Diseases CommonsPain Management CommonsPharmacoeconomics and Pharmaceutical Economics CommonsPsychiatric and Mental Health Commons. Advanced Search. Home About FAQ My Account Accessibility Statement. Privacy Copyright. Skip to main content. Home About FAQ My Account Contact Us. Title Predictors and Health Outcomes of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder.
Author Drishti ShahWest Virginia University Follow. Abstract Understanding major depressive disorder MDD as a comorbidity in patients with chronic non-cancer pain conditions CNPC is of importance because of the high prevalence and well documented bi-directional relationship between MDD and pain. Recommended Citation Shah, Drishti, "Predictors and Health Outcomes of Treatment-Resistant Depression among Adults with Chronic Non-Cancer Pain Conditions and Major Depressive Disorder" DOWNLOADS Since May 03, Included in Clinical Psychology Commonsphd dissertation cnpc, Epidemiology CommonsMental Disorders CommonsMusculoskeletal Diseases Commonsphd dissertation cnpc, Pain Management CommonsPharmacoeconomics and Pharmaceutical Economics CommonsPsychiatric and Mental Health Commons.
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